InnateDB Protein
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IDBP-23399.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SIN3A
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Protein Name
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SIN3 homolog A, transcription regulator (yeast)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000353622
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InnateDB Gene
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IDBG-23397 (SIN3A)
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Protein Structure
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Function |
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. {ECO:0000269PubMed:12150998}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00810, ECO:0000269PubMed:16820529}. Nucleus, nucleolus {ECO:0000269PubMed:16820529}. Note=Recruited to the nucleolus by SAP30L.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 262 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
Experimentally validated |
Total |
262
[view]
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Protein-Protein |
260
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
42 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000976
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transcription regulatory region sequence-specific DNA binding
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GO:0001102
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RNA polymerase II activating transcription factor binding
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GO:0003714
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transcription corepressor activity
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GO:0005515
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protein binding
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GO:0033558
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protein deacetylase activity
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0002218
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activation of innate immune response
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GO:0002230
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positive regulation of defense response to virus by host
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GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006476
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protein deacetylation
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GO:0007596
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blood coagulation
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GO:0031937
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positive regulation of chromatin silencing
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GO:0042754
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negative regulation of circadian rhythm
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GO:0044255
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cellular lipid metabolic process
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GO:0044281
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small molecule metabolic process
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0048511
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rhythmic process
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GO:1900181
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negative regulation of protein localization to nucleus
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GO:1901675
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negative regulation of histone H3-K27 acetylation
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GO:2000678
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negative regulation of transcription regulatory region DNA binding
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Cellular Component |
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PDB ID |
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InterPro |
IPR003822
Paired amphipathic helix
IPR013194
Histone deacetylase interacting
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PFAM |
PF02671
PF08295
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PRINTS |
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PIRSF |
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SMART |
SM00761
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TIGRFAMs |
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Modification |
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SwissProt |
Q96ST3
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PhosphoSite |
PhosphoSite-Q96ST3
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TrEMBL |
H3BT34
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UniProt Splice Variant |
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Entrez Gene |
25942
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UniGene |
Hs.678193
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RefSeq |
NP_001138829
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HUGO |
HGNC:19353
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OMIM |
607776
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CCDS |
CCDS10279
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HPRD |
09690
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IMGT |
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EMBL |
AC068338
AC105137
AF418569
AK027559
AK074903
AK096477
AL117513
AY044430
BC018973
BC137098
BC137099
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GenPept |
AAH18973
AAI37099
AAI37100
AAK95854
AAP97288
BAB55197
BAC04801
BAC11280
CAB55972
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