Version 5.4
Homo sapiens Protein: TMEM55B
Summary
InnateDB Protein IDBP-234056.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM55B
Protein Name transmembrane protein 55B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000381102
InnateDB Gene IDBG-2255 (TMEM55B)
Protein Structure
UniProt Annotation
Function Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4- bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3- monophosphate. {ECO:0000269PubMed:16365287}.
Subcellular Localization Late endosome membrane {ECO:0000269PubMed:16365287}; Multi-pass membrane protein {ECO:0000269PubMed:16365287}. Lysosome membrane {ECO:0000269PubMed:16365287}; Multi-pass membrane protein {ECO:0000269PubMed:16365287}.
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:16365287}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005765 lysosomal membrane
GO:0016021 integral component of membrane
GO:0031902 late endosome membrane
Protein Structure and Domains
PDB ID
InterPro IPR019178 Transmembrane protein 55A/B
PFAM PF09788
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86T03
PhosphoSite PhosphoSite-Q86T03
TrEMBL G3V5T5
UniProt Splice Variant
Entrez Gene 90809
UniGene Hs.7001
RefSeq NP_001094284
HUGO HGNC:19299
OMIM 609865
CCDS CCDS41911
HPRD 12660
IMGT
EMBL AK314021 AL137727 AL355075 BC002867 BC020947 BX161490 BX248025 CH471078
GenPept AAH02867 AAH20947 BAG36732 CAB70896 CAD61939 CAD62347 EAW66461

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca