InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD209

Summary

InnateDB Protein

IDBP-23424.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD209

Protein Name

CD209 molecule

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000346373

InnateDB Gene

IDBG-23414 (CD209)

Protein Structure

UniProt Annotation

Function

Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri- mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA.On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.

Subcellular Localization

Isoform 1: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.Isoform 2: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.Isoform 3: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.Isoform 4: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.Isoform 5: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.Isoform 6: Secreted {ECO:0000305}.Isoform 7: Secreted {ECO:0000305}.Isoform 8: Secreted {ECO:0000305}.Isoform 9: Secreted {ECO:0000305}.Isoform 10: Secreted {ECO:0000305}.Isoform 11: Secreted {ECO:0000305}.Isoform 12: Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes. {ECO:0000269PubMed:11257134, ECO:0000269PubMed:11337487}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005537	mannose binding
GO:0030246	carbohydrate binding
GO:0042605	peptide antigen binding
GO:0046790	virion binding
GO:0046872	metal ion binding

Biological Process

GO:0006897	endocytosis
GO:0007157	heterophilic cell-cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0009988	cell-cell recognition
GO:0019048	modulation by virus of host morphology or physiology
GO:0019062	virion attachment to host cell
GO:0019079	viral genome replication
GO:0019882	antigen processing and presentation
GO:0035556	intracellular signal transduction
GO:0042129	regulation of T cell proliferation
GO:0045087	innate immune response (InnateDB)
GO:0046968	peptide antigen transport
GO:0075733	intracellular transport of virus