Version 5.4
Homo sapiens Protein: PRKRIP1
Summary
InnateDB Protein IDBP-234310.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKRIP1
Protein Name PRKR interacting protein 1 (IL11 inducible)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000381010
InnateDB Gene IDBG-33544 (PRKRIP1)
Protein Structure
UniProt Annotation
Function Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleolus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003725 double-stranded RNA binding
GO:0004860 protein kinase inhibitor activity
GO:0019901 protein kinase binding
Biological Process
GO:0003014 renal system process
GO:0006469 negative regulation of protein kinase activity
GO:0042326 negative regulation of phosphorylation
Cellular Component
GO:0005730 nucleolus
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR009548 Protein of unknown function DUF1168
PFAM PF06658
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H875
PhosphoSite PhosphoSite-Q9H875
TrEMBL A0A024QYV5
UniProt Splice Variant
Entrez Gene 79706
UniGene
RefSeq NP_078929
HUGO HGNC:21894
OMIM
CCDS CCDS34714
HPRD 11460
IMGT
EMBL AK023964 AL833837 BC014298 CH471197
GenPept AAH14298 BAB14742 CAD38697 EAW50241 EAW50243

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca