InnateDB Protein
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IDBP-234575.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MED13
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Protein Name
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mediator complex subunit 13
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Synonyms
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ARC250; DRIP250; HSPC221; THRAP1; TRAP240;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000380888
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InnateDB Gene
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IDBG-62711 (MED13)
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Protein Structure
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Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269PubMed:16595664}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. {ECO:0000269PubMed:10198638}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
58
[view]
|
Protein-Protein |
57
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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|
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Molecular Function |
Accession |
GO Term |
GO:0001104
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RNA polymerase II transcription cofactor activity
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GO:0003712
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transcription cofactor activity
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GO:0003713
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transcription coactivator activity
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GO:0004872
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receptor activity
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GO:0030374
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ligand-dependent nuclear receptor transcription coactivator activity
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GO:0042809
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vitamin D receptor binding
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GO:0046966
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thyroid hormone receptor binding
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Biological Process |
GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006367
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transcription initiation from RNA polymerase II promoter
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GO:0010467
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gene expression
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GO:0030518
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intracellular steroid hormone receptor signaling pathway
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GO:0030521
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androgen receptor signaling pathway
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
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InterPro |
IPR009401
Mediator complex, subunit Med13
IPR021643
Mediator complex, subunit Med13, N-terminal, metazoa/fungi
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PFAM |
PF06333
PF11597
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UHV7
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PhosphoSite |
PhosphoSite-Q9UHV7
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TrEMBL |
A0A024QZ75
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UniProt Splice Variant |
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Entrez Gene |
9969
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UniGene |
Hs.706379
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RefSeq |
NP_005112
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HUGO |
HGNC:22474
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OMIM |
603808
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CCDS |
CCDS42366
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HPRD |
07229
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IMGT |
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EMBL |
AB011165
AC008158
AC018628
AC060798
AF117754
BC140891
CH471179
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GenPept |
AAD22032
AAI40892
BAA25519
EAW51438
EAW51439
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