InnateDB Protein
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IDBP-235045.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RASSF7
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Protein Name
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Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
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Synonyms
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C11orf13; HRAS1; HRC1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000380713
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InnateDB Gene
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IDBG-17142 (RASSF7)
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Protein Structure
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Function |
Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti- apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization. {ECO:0000269PubMed:20629633, ECO:0000269PubMed:21278800}.
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Subcellular Localization |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:20629633}. Note=Colocalizes with gamma-tubulin.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000159
Ras-association
IPR029071
Ubiquitin-related domain
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PFAM |
PF00788
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PRINTS |
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PIRSF |
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SMART |
SM00314
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TIGRFAMs |
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Modification |
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SwissProt |
Q02833
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PhosphoSite |
PhosphoSite-Q02833
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TrEMBL |
E9PM39
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UniProt Splice Variant |
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Entrez Gene |
8045
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UniGene |
Hs.72925
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RefSeq |
NP_003466
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HUGO |
HGNC:1166
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OMIM |
143023
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CCDS |
CCDS7702
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HPRD |
00878
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IMGT |
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EMBL |
AP006284
BC106921
BC106922
CH471158
M91083
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GenPept |
AAA58667
AAI06922
AAI06923
EAX02348
EAX02350
EAX02351
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