Version 5.4
Homo sapiens Protein: RASSF7
Summary
InnateDB Protein IDBP-235047.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RASSF7
Protein Name Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
Synonyms C11orf13; HRAS1; HRC1;
Species Homo sapiens
Ensembl Protein ENSP00000380712
InnateDB Gene IDBG-17142 (RASSF7)
Protein Structure
UniProt Annotation
Function Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti- apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization. {ECO:0000269PubMed:20629633, ECO:0000269PubMed:21278800}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:20629633}. Note=Colocalizes with gamma-tubulin.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
Protein Structure and Domains
PDB ID
InterPro IPR000159 Ras-association
IPR029071 Ubiquitin-related domain
PFAM PF00788
PRINTS
PIRSF
SMART SM00314
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q02833
PhosphoSite PhosphoSite-Q02833
TrEMBL E9PM39
UniProt Splice Variant
Entrez Gene 8045
UniGene Hs.72925
RefSeq NP_001137465
HUGO HGNC:1166
OMIM 143023
CCDS CCDS44506
HPRD 00878
IMGT
EMBL AP006284 BC106921 BC106922 CH471158 M91083
GenPept AAA58667 AAI06922 AAI06923 EAX02351

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca