InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WEE2

Summary

InnateDB Protein

IDBP-235170.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WEE2

Protein Name

WEE1 homolog 2 (S. pombe)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000380675

InnateDB Gene

IDBG-235168 (WEE2)

Protein Structure

UniProt Annotation

Function

Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11029659}.

Disease Associations

Tissue Specificity

Expressed in testis. {ECO:0000269PubMed:11029659}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007067	mitotic nuclear division
GO:0007143	female meiotic division
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0035038	female pronucleus assembly
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0060631	regulation of meiosis I
GO:1900194	negative regulation of oocyte maturation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR017164 Wee1-like protein kinase
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

PIRSF037281

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References