Version 5.4
| Homo sapiens Protein: TPSD1 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-235190.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | TPSD1 | ||||||||
| Protein Name | tryptase delta 1 | ||||||||
| Synonyms | MCP7-LIKE; MCP7L1; MMCP-7L; | ||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Protein | ENSP00000380668 | ||||||||
| InnateDB Gene | IDBG-8737 (TPSD1) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. {ECO:0000250}. | ||||||||
| Subcellular Localization | Secreted {ECO:0000250}. Note=Released from the secretory granules upon mast cell activation. {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Expressed in colon, lung, heart and synovial tissue. May be specific to mast cells. {ECO:0000269PubMed:12391231}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR001254
Peptidase S1 IPR001314 Peptidase S1A, chymotrypsin-type IPR009003 Trypsin-like cysteine/serine peptidase domain |
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| PFAM |
PF00089
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| PRINTS |
PR00722
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| PIRSF | |||||||||
| SMART |
SM00020
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q9BZJ3 | ||||||||
| PhosphoSite | PhosphoSite-Q9BZJ3 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 23430 | ||||||||
| UniGene | |||||||||
| RefSeq | |||||||||
| HUGO | HGNC:14118 | ||||||||
| OMIM | 609272 | ||||||||
| CCDS | |||||||||
| HPRD | 08345 | ||||||||
| IMGT | |||||||||
| EMBL | AC120498 AE006466 AF098327 AF099147 AF206664 AF318074 AF421357 AY055427 | ||||||||
| GenPept | AAD17845 AAD17861 AAG35694 AAK12909 AAK61272 AAL17874 AAL86695 | ||||||||