InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC22A18

Summary

InnateDB Protein

IDBP-23538.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC22A18

Protein Name

solute carrier family 22, member 18

Synonyms

BWR1A; BWSCR1A; HET; IMPT1; ITM; ORCTL2; p45-BWR1A; SLC22A1L; TSSC5;

Species

Homo sapiens

Ensembl Protein

ENSP00000307859

InnateDB Gene

IDBG-23534 (SLC22A18)

Protein Structure

UniProt Annotation

Function

May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. {ECO:0000269PubMed:9744804}.

Subcellular Localization

Apical cell membrane {ECO:0000305}; Multi- pass membrane protein {ECO:0000305}. Note=Localized at the apical membrane surface of renal proximal tubules. {ECO:0000269PubMed:9744804}.

Disease Associations

Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. {ECO:0000269PubMed:9751628}. Note=The gene represented in this entry may be involved in disease pathogenesis.Rhabdomyosarcoma, embryonal, 1 (RMSE1) [MIM:268210]: A form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchymal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed at high levels in adult and fetal kidney and liver, and adult colon. Expressed in fetal renal proximal tubules (at protein level). Expressed at lower levels in heart, brain and lung. {ECO:0000269PubMed:9499412, ECO:0000269PubMed:9520460, ECO:0000269PubMed:9570947, ECO:0000269PubMed:9744804}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015238	drug transmembrane transporter activity
GO:0015293	symporter activity
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006855	drug transmembrane transport
GO:0007588	excretion
GO:0015695	organic cation transport
GO:0015893	drug transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001958 Tetracycline resistance protein, TetA/multidrug resistance protein MdtG
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF07690

PRINTS

PR01035

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96BI1