InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AKAP8L

Summary

InnateDB Protein

IDBP-235393.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKAP8L

Protein Name

A kinase (PRKA) anchor protein 8-like

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000380557

InnateDB Gene

IDBG-34624 (AKAP8L)

Protein Structure

UniProt Annotation

Function

Could play a role in constitutive transport element (CTE)-mediated gene expression. Does not seem to be implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and chromatin condensation. May regulate the initiation phase of DNA replication when associated with TMPO-beta.

Subcellular Localization

Nucleus matrix. Cytoplasm. Note=Colocalizes with PRPF40A in the nuclear matrix (By similarity). Nuclear at steady state but shuttles between the nucleus and cytoplasm. Associated with the nuclear matrix. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the brain cortex (at protein level). {ECO:0000269PubMed:16391387}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.

Experimentally validated
Total	30 [view]
Protein-Protein	29 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0017151	DEAD/H-box RNA helicase binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding