InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HTR1A

Summary

InnateDB Protein

IDBP-23548.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HTR1A

Protein Name

5-hydroxytryptamine (serotonin) receptor 1A

Synonyms

5-HT-1A; 5-HT1A; 5HT1a; ADRB2RL1; ADRBRL1; G-21; PFMCD;

Species

Homo sapiens

Ensembl Protein

ENSP00000316244

InnateDB Gene

IDBG-23546 (HTR1A)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5- hydroxytryptamine release and in the regulation of dopamine and 5- hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. {ECO:0000269PubMed:22957663, ECO:0000269PubMed:3138543, ECO:0000269PubMed:8138923, ECO:0000269PubMed:8393041}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:22957663, ECO:0000269PubMed:3041227, ECO:0000269PubMed:3138543, ECO:0000269PubMed:8393041}; Multi-pass membrane protein {ECO:0000269PubMed:22957663, ECO:0000269PubMed:3041227, ECO:0000269PubMed:3138543, ECO:0000269PubMed:8393041}.

Disease Associations

Periodic fever, menstrual cycle-dependent (PFMC) [MIM:614674]: A condition characterized by recurrent fevers up to 40 degrees Celsius associated with the luteal phase of the menstrual cycle. Women show menstrual cycle-dependent physiologic changes in relation to sex hormone levels. Because ovulation triggers a significant change in the hormonal milieu that is similar to local inflammation, a 0.5 to 1.0 degree Celsius increase in basal body temperature after ovulation is commonly associated with progesterone secretion and is believed to be triggered by the induction of several inflammatory cytokines. {ECO:0000269PubMed:21990073}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells. {ECO:0000269PubMed:3041227, ECO:0000269PubMed:8393041}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004993	serotonin receptor activity
GO:0005515	protein binding

Biological Process

GO:0001662	behavioral fear response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway
GO:0007210	serotonin receptor signaling pathway
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0014062	regulation of serotonin secretion
GO:0035640	exploration behavior
GO:0042053	regulation of dopamine metabolic process
GO:0042310	vasoconstriction
GO:0042428	serotonin metabolic process
GO:0046883	regulation of hormone secretion
GO:0050795	regulation of behavior

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000610 5-Hydroxytryptamine 1A receptor
IPR000611 Neuropeptide Y receptor family
IPR002231 5-hydroxytryptamine receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00512
PR01012
PR01101

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P08908