InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MEIOB

Summary

InnateDB Protein

IDBP-235576.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MEIOB

Protein Name

chromosome 16 open reading frame 73

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000380504

InnateDB Gene

IDBG-9383 (MEIOB)

Protein Structure

UniProt Annotation

Function

Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Co-localizes with the RPA complex on meiotic chromosome axes. Accumulates on resected DNA. Localization is dependent on SPATA22 (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

In fetal gonads, specifically expressed in the ovary starting at the 14th weeks post fertilization. {ECO:0000269PubMed:24068956}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003697	single-stranded DNA binding
GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity

Biological Process

GO:0000712	resolution of meiotic recombination intermediates
GO:0000724	double-strand break repair via homologous recombination
GO:0000738	DNA catabolic process, exonucleolytic
GO:0007129	synapsis
GO:0007140	male meiosis
GO:0007144	female meiosis I
GO:0009566	fertilization