InnateDB Protein
|
IDBP-235616.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
GALNT9
|
Protein Name
|
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000380488
|
InnateDB Gene
|
IDBG-65443 (GALNT9)
|
Protein Structure
|
|
Function |
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Does not glycosylate apomucin or SDC3.
|
Subcellular Localization |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Specifically expressed in brain. Not expressed in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte. In brain, it is expressed in cerebellum, frontal lobe, temporal lobe, putamen and spinal cord, weakly expressed in cerebral cortex. Not expressed in medulla and occipital pole. {ECO:0000269PubMed:10978536}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
|
Molecular Function |
Accession |
GO Term |
GO:0004653
|
polypeptide N-acetylgalactosaminyltransferase activity
|
GO:0046872
|
metal ion binding
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000772
Ricin B lectin domain
IPR029044
Nucleotide-diphospho-sugar transferases
|
PFAM |
PF00652
PF14200
|
PRINTS |
|
PIRSF |
|
SMART |
SM00458
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9HCQ5
|
PhosphoSite |
PhosphoSite-Q9HCQ5
|
TrEMBL |
F5H557
|
UniProt Splice Variant |
|
Entrez Gene |
50614
|
UniGene |
Hs.301062
|
RefSeq |
NP_068580
|
HUGO |
HGNC:4131
|
OMIM |
606251
|
CCDS |
CCDS41866
|
HPRD |
|
IMGT |
|
EMBL |
AB040672
AC138466
AC148477
AC232989
AF458594
BC093817
BC093819
|
GenPept |
AAH93817
AAH93819
AAM49722
BAB13699
|
|
|