InnateDB Protein
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IDBP-235801.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DEK
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Protein Name
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DEK oncogene
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Synonyms
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D6S231E;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000380414
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InnateDB Gene
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IDBG-64038 (DEK)
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Protein Structure
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Function |
Involved in chromatin organization. {ECO:0000269PubMed:17524367}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:17524367, ECO:0000269PubMed:19695025}. Note=Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei.
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Disease Associations |
Note=A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non- lymphocytic leukemia. Translocation t(6;9)(p23;q34) with NUP214/CAN. It results in the formation of a DEK-CAN fusion gene.
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Tissue Specificity |
Ubiquitous. Expressed at relatively high levels.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
43
[view]
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Protein-Protein |
43
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0007165
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signal transduction
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GO:0016568
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chromatin modification
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GO:0019079
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viral genome replication
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GO:2000779
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regulation of double-strand break repair
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GO:2001032
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regulation of double-strand break repair via nonhomologous end joining
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Cellular Component |
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PDB ID |
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InterPro |
IPR003034
SAP domain
IPR014876
DEK, C-terminal
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PFAM |
PF02037
PF08766
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PRINTS |
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PIRSF |
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SMART |
SM00513
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TIGRFAMs |
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Modification |
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SwissProt |
P35659
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PhosphoSite |
PhosphoSite-P35659
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TrEMBL |
D6RDA2
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UniProt Splice Variant |
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Entrez Gene |
7913
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UniGene |
Hs.718522
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RefSeq |
NP_003463
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HUGO |
HGNC:2768
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OMIM |
125264
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CCDS |
CCDS34344
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HPRD |
00503
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IMGT |
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EMBL |
AK297749
AK312616
AL031774
BC035259
CH471087
X64229
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GenPept |
AAH35259
BAG35503
BAG60099
CAA45536
CAI20082
EAW55402
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