Version 5.4
Homo sapiens Protein: FOXRED2
Summary
InnateDB Protein IDBP-235829.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOXRED2
Protein Name FAD-dependent oxidoreductase domain containing 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000380400
InnateDB Gene IDBG-5956 (FOXRED2)
Protein Structure
UniProt Annotation
Function Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation. {ECO:0000269PubMed:19706418}.
Subcellular Localization Endoplasmic reticulum lumen {ECO:0000255PROSITE-ProRule:PRU10138, ECO:0000269PubMed:19706418}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005788 endoplasmic reticulum lumen
Protein Structure and Domains
PDB ID
InterPro IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain
PFAM PF07992
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IWF2
PhosphoSite PhosphoSite-Q8IWF2
TrEMBL B0QYA2
UniProt Splice Variant
Entrez Gene 80020
UniGene Hs.387601
RefSeq
HUGO HGNC:26264
OMIM 613777
CCDS CCDS13929
HPRD 08666
IMGT
EMBL AK025714 AK026975 AK315555 AL022313 BC015726 BC027716 BC040351 CH471095 CR456444
GenPept AAH15726 AAH27716 AAH40351 BAB15227 BAB15610 BAG37931 CAG30330 CAI19228 EAW60106

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca