InnateDB Protein
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IDBP-23583.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PDE7A
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Protein Name
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phosphodiesterase 7A
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Synonyms
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HCP1; PDE7;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000368730
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InnateDB Gene
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IDBG-23581 (PDE7A)
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Protein Structure
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Function |
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction. {ECO:0000269PubMed:19350606}.
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Subcellular Localization |
Isoform PDE7A1: Cytoplasm, cytosol. Note=PDE7A1 (57 kDa) is located mostly to soluble cellular fractions.Isoform PDE7A2: Cytoplasm. Note=PDE7A2 (50 kDa) is located to particulate cellular fractions.
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Disease Associations |
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Tissue Specificity |
PDE7A1 is found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. PDE7A2 is found abundantly in skeletal muscle and at low levels in heart.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004114
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3',5'-cyclic-nucleotide phosphodiesterase activity
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GO:0004115
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3',5'-cyclic-AMP phosphodiesterase activity
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GO:0046872
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metal ion binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002073
3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607
HD/PDEase domain
IPR023088
3\'5\'-cyclic nucleotide phosphodiesterase
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PFAM |
PF00233
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PRINTS |
PR00387
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PIRSF |
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SMART |
SM00471
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TIGRFAMs |
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Modification |
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SwissProt |
Q13946
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PhosphoSite |
PhosphoSite-Q13946
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TrEMBL |
E5RG23
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UniProt Splice Variant |
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Entrez Gene |
5150
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UniGene |
Hs.728847
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RefSeq |
NP_002594
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HUGO |
HGNC:8791
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OMIM |
171885
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CCDS |
CCDS34901
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HPRD |
01386
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IMGT |
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EMBL |
AC055822
AC100812
AF332652
AK290801
AK292680
BC126360
L12052
U67932
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GenPept |
AAA35644
AAB65772
AAI26361
AAK57640
BAF83490
BAF85369
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