InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TEAD4

Summary

InnateDB Protein

IDBP-236067.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TEAD4

Protein Name

TEA domain family member 4

Synonyms

EFTR-2; hRTEF-1B; RTEF1; TCF13L1; TEF-3; TEF3; TEFR-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000380311

InnateDB Gene

IDBG-12612 (TEAD4)

Protein Structure

UniProt Annotation

Function

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. {ECO:0000269PubMed:18579750, ECO:0000269PubMed:19324877}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0001501	skeletal system development
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007517	muscle organ development
GO:0010467	gene expression
GO:0035329	hippo signaling