InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNX33

Summary

InnateDB Protein

IDBP-23608.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNX33

Protein Name

sorting nexin 33

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000311427

InnateDB Gene

IDBG-23606 (SNX33)

Protein Structure

UniProt Annotation

Function

Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes. {ECO:0000269PubMed:18353773, ECO:0000269PubMed:18419754, ECO:0000269PubMed:19487689, ECO:0000269PubMed:20964629, ECO:0000269PubMed:21048941, ECO:0000269PubMed:22718350}.

Subcellular Localization

Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Primarily cytosolic, but a minor proportion is membrane-bound (PubMed:18353773). Not associated with membranes (PubMed:21048941). {ECO:0000269PubMed:18353773, ECO:0000269PubMed:21048941}.

Disease Associations

Tissue Specificity

Detected in heart and pancreas. {ECO:0000269PubMed:18353773}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0035091	phosphatidylinositol binding
GO:0042802	identical protein binding

Biological Process

GO:0000281	mitotic cytokinesis
GO:0006886	intracellular protein transport
GO:0006897	endocytosis
GO:0007032	endosome organization
GO:0007067	mitotic nuclear division
GO:0015031	protein transport
GO:0016197	endosomal transport
GO:0036089	cleavage furrow formation
GO:0044351	macropinocytosis
GO:0097320	membrane tubulation

Cellular Component

GO:0005768	endosome
GO:0005829	cytosol
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0019898	extrinsic component of membrane
GO:0030659	cytoplasmic vesicle membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001452 SH3 domain
IPR001683 Phox homologous domain
IPR011511 Variant SH3 domain
IPR014536 Sorting nexin 9 subfamily
IPR019497 Sorting nexin protein, WASP-binding domain

PFAM

PF00018
PF14604
PF00787
PF07653
PF10456

PRINTS

PR00452

PIRSF

PIRSF027744

SMART

SM00326
SM00312

TIGRFAMs

Post-translational Modifications

Modification

Cross-References