InnateDB Protein
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IDBP-236089.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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JPH4
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Protein Name
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junctophilin 4
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000380307
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InnateDB Gene
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IDBG-3382 (JPH4)
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Protein Structure
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Function |
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003409
MORN motif
IPR017191
Junctophilin
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PFAM |
PF02493
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PRINTS |
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PIRSF |
PIRSF037387
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SMART |
SM00698
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TIGRFAMs |
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Modification |
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SwissProt |
Q96JJ6
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PhosphoSite |
PhosphoSite-Q96JJ6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
84502
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UniGene |
Hs.719358
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RefSeq |
NP_115828
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HUGO |
HGNC:20156
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OMIM |
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CCDS |
CCDS9603
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HPRD |
17170
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IMGT |
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EMBL |
AB058734
AK055345
AL834411
BC055429
CH471078
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GenPept |
AAH55429
BAB47460
BAB70905
CAD39073
EAW66135
EAW66139
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