InnateDB Protein
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IDBP-236140.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DHRS4
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Protein Name
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dehydrogenase/reductase (SDR family) member 4
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000380264
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InnateDB Gene
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IDBG-3418 (DHRS4)
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Protein Structure
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Function |
Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co- factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). {ECO:0000250}.
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Subcellular Localization |
Peroxisome {ECO:0000269PubMed:10333503}. Note=Isoform 1 is peroxisomal, while isoform 4 is not.Isoform 7: Nucleus {ECO:0000269PubMed:22227495}.
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Disease Associations |
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Tissue Specificity |
Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressed in a few neoplastic cervical tissues.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000253
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3-keto sterol reductase activity
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GO:0004090
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carbonyl reductase (NADPH) activity
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GO:0005102
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receptor binding
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GO:0016491
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oxidoreductase activity
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GO:0016655
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oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
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GO:0018455
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alcohol dehydrogenase [NAD(P)+] activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002198
Short-chain dehydrogenase/reductase SDR
IPR013968
Polyketide synthase, KR
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PFAM |
PF00106
PF08659
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PRINTS |
PR00080
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PIRSF |
PIRSF000126
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BTZ2
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PhosphoSite |
PhosphoSite-Q9BTZ2
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TrEMBL |
J3QST2
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UniProt Splice Variant |
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Entrez Gene |
728635
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UniGene |
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RefSeq |
NP_001269920
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HUGO |
HGNC:16985
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OMIM |
615195
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CCDS |
CCDS61412
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HPRD |
07484
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IMGT |
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EMBL |
AB045131
AF044127
AF064256
AK001870
AK314448
AL136419
AY071856
AY358638
AY616182
AY943857
BC003019
DQ325464
DQ338571
DQ344810
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GenPept |
AAD02292
AAH03019
AAL61824
AAQ13444
AAQ89001
AAT70757
AAX49568
ABC61320
ABC61321
ABD75823
BAA91953
BAB18775
BAG37057
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