InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UPF2

Summary

InnateDB Protein

IDBP-236148.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UPF2

Protein Name

UPF2 regulator of nonsense transcripts homolog (yeast)

Synonyms

HUPF2; RENT2; smg-3;

Species

Homo sapiens

Ensembl Protein

ENSP00000380244

InnateDB Gene

IDBG-53271 (UPF2)

Protein Structure

UniProt Annotation

Function

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA. {ECO:0000269PubMed:11163187, ECO:0000269PubMed:16209946, ECO:0000269PubMed:18066079}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000269PubMed:11073994, ECO:0000269PubMed:11113196, ECO:0000269PubMed:11163187}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:11073994}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 111 experimentally validated interaction(s) in this database.

Experimentally validated
Total	111 [view]
Protein-Protein	111 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006406	mRNA export from nucleus
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process