Version 5.4
Homo sapiens Protein: AGPAT6
Summary
InnateDB Protein IDBP-236337.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AGPAT6
Protein Name 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000380184
InnateDB Gene IDBG-18974 (AGPAT6)
Protein Structure
UniProt Annotation
Function Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long- chain fatty acyl-CoAs. {ECO:0000269PubMed:18238778}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:18238778}; Multi-pass membrane protein {ECO:0000269PubMed:18238778}.
Disease Associations
Tissue Specificity Ubiquitous. Relatively high level of expression in skeletal muscle, heart and testis. Relatively low level of expression in lung. {ECO:0000269PubMed:12938015, ECO:0000269PubMed:18238778}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004366 glycerol-3-phosphate O-acyltransferase activity
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0002071 glandular epithelial cell maturation
GO:0006631 fatty acid metabolic process
GO:0006637 acyl-CoA metabolic process
GO:0006641 triglyceride metabolic process
GO:0006644 phospholipid metabolic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0007595 lactation
GO:0008152 metabolic process
GO:0008610 lipid biosynthetic process
GO:0016024 CDP-diacylglycerol biosynthetic process
GO:0019432 triglyceride biosynthetic process
GO:0030879 mammary gland development
GO:0040014 regulation of multicellular organism growth
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0046339 diacylglycerol metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR002123 Phospholipid/glycerol acyltransferase
PFAM PF01553
PRINTS
PIRSF
SMART SM00563
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86UL3
PhosphoSite PhosphoSite-Q86UL3
TrEMBL Q8NDD3
UniProt Splice Variant
Entrez Gene 137964
UniGene Hs.355753
RefSeq NP_848934
HUGO HGNC:20880
OMIM 608143
CCDS CCDS6117
HPRD 12175
IMGT
EMBL AC009630 AF406612 AL834255 AY358670 AY513610 BC051377 BC061884 CH471080
GenPept AAH51377 AAH61884 AAP21893 AAQ89033 AAS82774 CAD38930 EAW63254 EAW63255

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca