InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HIST1H2BC

Summary

InnateDB Protein

IDBP-236350.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HIST1H2BC

Protein Name

histone cluster 1, H2bc

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000380180

InnateDB Gene

IDBG-67850 (HIST1H2BC)

Protein Structure

UniProt Annotation

Function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.

Subcellular Localization

Nucleus. Chromosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	23 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0002227	innate immune response in mucosa
GO:0006325	chromatin organization
GO:0006334	nucleosome assembly
GO:0019731	antibacterial humoral response
GO:0050830	defense response to Gram-positive bacterium

Cellular Component

GO:0000786	nucleosome
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0070062	extracellular vesicular exosome