InnateDB Protein
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IDBP-236360.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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UBE2G1
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Protein Name
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ubiquitin-conjugating enzyme E2G 1
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Synonyms
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E217K; UBC7; UBE2G;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000380178
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InnateDB Gene
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IDBG-18727 (UBE2G1)
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Protein Structure
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Function |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4. {ECO:0000269PubMed:19103148, ECO:0000269PubMed:20061386}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Widely expressed, mainly in skeletal muscle. {ECO:0000269PubMed:8893823}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
20
[view]
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Protein-Protein |
19
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000608
Ubiquitin-conjugating enzyme, E2
IPR016135
Ubiquitin-conjugating enzyme/RWD-like
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PFAM |
PF00179
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P62253
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PhosphoSite |
PhosphoSite-P62253
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TrEMBL |
K7EPR7
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UniProt Splice Variant |
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Entrez Gene |
7326
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UniGene |
Hs.741319
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RefSeq |
NP_003333
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HUGO |
HGNC:12482
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OMIM |
601569
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CCDS |
CCDS32532
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HPRD |
03340
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IMGT |
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EMBL |
AC087742
AC116910
AK313059
BC002775
BC026288
BT007416
CH471108
D78514
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GenPept |
AAH02775
AAH26288
AAP36084
BAA11410
BAG35889
EAW90441
EAW90445
EAW90446
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