Version 5.4
Homo sapiens Protein: OR51E2
Summary
InnateDB Protein IDBP-236434.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OR51E2
Protein Name olfactory receptor, family 51, subfamily E, member 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000380153
InnateDB Gene IDBG-25196 (OR51E2)
Protein Structure
UniProt Annotation
Function Probable G protein-coupled receptor that is activated by the short chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498). May also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702). May also function as an olfactory receptor being activated by beta-ionone (PubMed:19389702). {ECO:0000269PubMed:19389702, ECO:0000269PubMed:23401498}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:23401498}; Multi-pass membrane protein {ECO:0000269PubMed:23401498}.
Disease Associations
Tissue Specificity Mainly expressed in the prostate. Also expressed in spleen, liver, olfactory epithelium and medulla oblongata. {ECO:0000269PubMed:11707321, ECO:0000269PubMed:16491480}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003707 steroid hormone receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004984 olfactory receptor activity
GO:0038023 signaling receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0043401 steroid hormone mediated signaling pathway
GO:0045777 positive regulation of blood pressure
GO:0050911 detection of chemical stimulus involved in sensory perception of smell
GO:0071398 cellular response to fatty acid
GO:1900135 positive regulation of renin secretion into blood stream
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000725 Olfactory receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
PFAM PF00001
PF10320
PRINTS PR00237
PR00245
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H255
PhosphoSite PhosphoSite-
TrEMBL E9PPJ8
UniProt Splice Variant
Entrez Gene 81285
UniGene Hs.501758
RefSeq NP_110401
HUGO HGNC:15195
OMIM 611268
CCDS CCDS7751
HPRD 17736
IMGT
EMBL AC090719 AF311306 AF369708 AK314051 AY033942 BC020768 BK004368 CH471064
GenPept AAG40776 AAH20768 AAK38728 AAK57550 BAG36760 DAA04766 EAW68829

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca