InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NFKBID

Summary

InnateDB Protein

IDBP-236525.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFKBID

Protein Name

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000380109

InnateDB Gene

IDBG-45939 (NFKBID)

Protein Structure

UniProt Annotation

Function

May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR- induced negative selection of thymocytes (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0051059	NF-kappaB binding

Biological Process

GO:0006954	inflammatory response
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0033085	negative regulation of T cell differentiation in thymus
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0070245	positive regulation of thymocyte apoptotic process