Version 5.4
Homo sapiens Protein: TRIM55
Summary
InnateDB Protein IDBP-23661.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM55
Protein Name tripartite motif containing 55
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000323913
InnateDB Gene IDBG-23653 (TRIM55)
Protein Structure
UniProt Annotation
Function May regulate gene expression and protein turnover in muscle cells. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Nuclear under atrophic conditions and upon mechanical signals. Localizes to the sarcomeric M-band in cardiomyocytes. Colocalizes in part with microtubules (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in muscle. Low-level expression in liver. {ECO:0000269PubMed:11243782}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 97 experimentally validated interaction(s) in this database.
Experimentally validated
Total 97 [view]
Protein-Protein 95 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0007165 signal transduction
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005874 microtubule
Protein Structure and Domains
PDB ID
InterPro IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF00643
PF13639
PF14634
PF00097
PRINTS
PIRSF
SMART SM00336
SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BYV6
PhosphoSite PhosphoSite-Q9BYV6
TrEMBL
UniProt Splice Variant
Entrez Gene 84675
UniGene Hs.85524
RefSeq NP_908973
HUGO HGNC:14215
OMIM 606469
CCDS CCDS6184
HPRD 05927
IMGT
EMBL AJ243488 AJ243489 AJ277493 AJ291712 AJ431704 AK091310 AK091728 BC007750 BT007212 CH471068
GenPept AAH07750 AAP35876 BAG52332 BAG52405 CAC32839 CAC32840 CAC43019 CAC43020 CAC81835 CAD24432 EAW86894 EAW86895

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca