Version 5.4
Homo sapiens Protein: CBY1
Summary
InnateDB Protein IDBP-236709.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CBY1
Protein Name chibby homolog 1 (Drosophila)
Synonyms arb1; C22orf2; CBY; HS508I15A; PGEA1; PIGEA-14; PIGEA14;
Species Homo sapiens
Ensembl Protein ENSP00000380026
InnateDB Gene IDBG-7651 (CBY1)
Protein Structure
UniProt Annotation
Function Inhibits the Wnt/Wingless pathway by binding to beta- catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. {ECO:0000269PubMed:12712206, ECO:0000269PubMed:15194699}.
Subcellular Localization Nucleus speckle. Golgi apparatus, trans- Golgi network. Note=Nuclear, in a punctate manner. Also found in the trans-Golgi.
Disease Associations
Tissue Specificity Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta. Also found in brain, lung, liver and testis. Significantly down-regulated in thyroid and metastatic uterine tumors. {ECO:0000269PubMed:12712206}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0042802 identical protein binding
Biological Process
GO:0008104 protein localization
GO:0030178 negative regulation of Wnt signaling pathway
GO:0045444 fat cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0055007 cardiac muscle cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005802 trans-Golgi network
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y3M2
PhosphoSite PhosphoSite-Q9Y3M2
TrEMBL B0QY54
UniProt Splice Variant
Entrez Gene 25776
UniGene Hs.743316
RefSeq
HUGO HGNC:1307
OMIM 607757
CCDS CCDS13974
HPRD 09676
IMGT
EMBL AB015347 AB111855 AF331041 AK311928 AL021707 AL050345 AL136686 BC016139 BK005534 CH471095 CR456410
GenPept AAH16139 AAL56062 BAA88119 BAC78839 BAG34869 CAB43547 CAB63442 CAB66621 CAG30296 DAA05582 EAW60254 EAW60255 EAW60256

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca