InnateDB Protein
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IDBP-236720.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TMBIM1
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Protein Name
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transmembrane BAX inhibitor motif containing 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000380025
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InnateDB Gene
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IDBG-80943 (TMBIM1)
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Protein Structure
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Function |
Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling.
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Subcellular Localization |
Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000269PubMed:16607040}. Endosome membrane {ECO:0000269PubMed:16607040}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005123
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death receptor binding
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Biological Process |
GO:0048553
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negative regulation of metalloenzyme activity
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GO:0090005
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negative regulation of establishment of protein localization to plasma membrane
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GO:1902042
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negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
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GO:1902045
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negative regulation of Fas signaling pathway
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GO:2000504
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positive regulation of blood vessel remodeling
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Cellular Component |
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PDB ID |
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InterPro |
IPR006214
Bax inhibitor 1-related
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PFAM |
PF01027
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q969X1
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PhosphoSite |
PhosphoSite-Q969X1
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TrEMBL |
F8WDY4
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UniProt Splice Variant |
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Entrez Gene |
64114
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UniGene |
Hs.591605
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RefSeq |
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HUGO |
HGNC:23410
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OMIM |
610364
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CCDS |
CCDS2412
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HPRD |
17884
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IMGT |
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EMBL |
AC021016
AF193045
AK027755
AK075465
AK090618
AK093911
AK095270
AK298123
AK298500
BC007980
BC013428
BC026348
BC026693
CH471063
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GenPept |
AAG22473
AAH07980
AAH13428
AAH26348
AAH26693
BAB55346
BAC04516
BAC11636
BAG52198
BAG52782
BAG60403
BAG60707
EAW70607
EAW70609
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