Version 5.4
Homo sapiens Protein: PION
Summary
InnateDB Protein IDBP-23675.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PION
Protein Name pigeon homolog (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000257626
InnateDB Gene IDBG-23696 (PION)
Protein Structure
UniProt Annotation
Function Regulator of gamma-secretase activity, which specifically activates the production of beta-amyloid protein (beta-amyloid protein 40 and beta-amyloid protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate beta- amyloid, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD. {ECO:0000269PubMed:20811458}.
Subcellular Localization Golgi apparatus, trans-Golgi network {ECO:0000269PubMed:20811458}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:20811458}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
Biological Process
GO:0030162 regulation of proteolysis
GO:1902004 positive regulation of beta-amyloid formation
Cellular Component
GO:0005802 trans-Golgi network
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A4D1B5
PhosphoSite PhosphoSite-A4D1B5
TrEMBL B7ZL33
UniProt Splice Variant
Entrez Gene 54103
UniGene Hs.186649
RefSeq NP_059135
HUGO HGNC:28042
OMIM 613552
CCDS CCDS34672
HPRD 18671
IMGT
EMBL AC004921 AC073635 AL079277 AL079297 AL834358 BC101499 BC143549 CH236949 CH471091
GenPept AAI01500 AAI43550 CAB45152 CAB45193 CAD39023 EAL24199 EAL24200 EAW77039

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca