InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP6V1H

Summary

InnateDB Protein

IDBP-236754.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V1H

Protein Name

ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000379995

InnateDB Gene

IDBG-21670 (ATP6V1H)

Protein Structure

UniProt Annotation

Function

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:9620685}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.

Experimentally validated
Total	31 [view]
Protein-Protein	30 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0016887	ATPase activity
GO:0030234	enzyme regulator activity
GO:0046961	proton-transporting ATPase activity, rotational mechanism

Biological Process

GO:0006200	ATP catabolic process
GO:0006879	cellular iron ion homeostasis
GO:0006897	endocytosis
GO:0007035	vacuolar acidification
GO:0008286	insulin receptor signaling pathway
GO:0015991	ATP hydrolysis coupled proton transport
GO:0016032	viral process
GO:0033572	transferrin transport
GO:0050690	regulation of defense response to virus by virus
GO:0050790	regulation of catalytic activity
GO:0051701	interaction with host
GO:0055085	transmembrane transport
GO:0090382	phagosome maturation

Cellular Component

GO:0000221	vacuolar proton-transporting V-type ATPase, V1 domain
GO:0005765	lysosomal membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome