InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MOG

Summary

InnateDB Protein

IDBP-236933.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MOG

Protein Name

myelin oligodendrocyte glycoprotein

Synonyms

BTN6; BTNL11; MOGIG2; NRCLP7;

Species

Homo sapiens

Ensembl Protein

ENSP00000379929

InnateDB Gene

IDBG-73515 (MOG)

Protein Structure

UniProt Annotation

Function

Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication. {ECO:0000250}.

Subcellular Localization

Isoform 1: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.Isoform 5: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.Isoform 2: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 3: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 4: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 6: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 7: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 8: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 9: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Narcolepsy 7 (NRCLP7) [MIM:614250]: Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye- movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. {ECO:0000269PubMed:21907016}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007417	central nervous system development
GO:0034126	positive regulation of MyD88-dependent toll-like receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR016663 Myelin-oligodendrocyte glycoprotein

PFAM

PF07686

PRINTS

PIRSF

PIRSF016522

SMART

SM00406
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt