Version 5.4
Homo sapiens Protein: SPEG
Summary
InnateDB Protein IDBP-236958.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPEG
Protein Name SPEG complex locus
Synonyms APEG-1; APEG1; BPEG; CNM5; SPEGalpha; SPEGbeta;
Species Homo sapiens
Ensembl Protein ENSP00000379917
InnateDB Gene IDBG-81742 (SPEG)
Protein Structure
UniProt Annotation
Function Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
Subcellular Localization Isoform 3: Nucleus.
Disease Associations
Tissue Specificity Isoform 1 is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 is predominantly expressed in the aorta. Isoform 3 appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC in vivo. In response to vascular injuries ASMC dedifferentiate and change from a quiescent and contractile phenotype to a proliferative and synthetic phenotype. This proliferation of vascular smooth muscle cells is one of the most prominent features of atherosclerosis. {ECO:0000269PubMed:15185077, ECO:0000269PubMed:8663449}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007517 muscle organ development
GO:0008285 negative regulation of cell proliferation
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
PFAM PF07679
PRINTS
PIRSF
SMART SM00408
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15772
PhosphoSite PhosphoSite-Q15772
TrEMBL
UniProt Splice Variant
Entrez Gene 10290
UniGene Hs.739097
RefSeq
HUGO HGNC:16901
OMIM 615950
CCDS CCDS54432
HPRD 10653
IMGT
EMBL AB037718 AC053503 AK126500 AK289531 AY603755 BC006346 CH471063 CR542201 DQ395348 U57099
GenPept AAC50599 AAH06346 AAT80901 AAY15052 ABD61734 BAA92535 BAC86568 BAF82220 CAG46998 EAW70747

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca