InnateDB Protein
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IDBP-237097.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ELP5
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Protein Name
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chromosome 17 open reading frame 81
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Synonyms
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C17orf81; DERP6; MST071; MSTP071;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000379868
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InnateDB Gene
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IDBG-23995 (ELP5)
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Protein Structure
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Function |
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation. {ECO:0000250, ECO:0000269PubMed:16850183}.
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Subcellular Localization |
Nucleus. Cytoplasm.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed with high levels in heart, brain, liver, skeletal muscle and testis.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
|
Protein-Protein |
8
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR019519
Elongator complex protein 5
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PFAM |
PF10483
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8TE02
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PhosphoSite |
PhosphoSite-Q8TE02
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TrEMBL |
I3NI50
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UniProt Splice Variant |
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Entrez Gene |
23587
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UniGene |
Hs.707224
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RefSeq |
NP_056177
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HUGO |
HGNC:30617
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OMIM |
615019
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CCDS |
CCDS11094
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HPRD |
08520
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IMGT |
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EMBL |
AB013910
AC003688
AF070658
AF087868
AF163262
AK289940
AL713741
BC002762
CH471108
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GenPept |
AAD20964
AAH02762
AAM10496
AAQ13591
BAB87800
BAF82629
CAH56280
EAW90230
EAW90231
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