InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNF143

Summary

InnateDB Protein

IDBP-237140.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNF143

Protein Name

zinc finger protein 143

Synonyms

pHZ-1; SBF; STAF;

Species

Homo sapiens

Ensembl Protein

ENSP00000379847

InnateDB Gene

IDBG-31360 (ZNF143)

Protein Structure

UniProt Annotation

Function

Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8. {ECO:0000269PubMed:17938208, ECO:0000269PubMed:9776743}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in all tissues tested, with the strongest expression in ovary.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	4 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006359	regulation of transcription from RNA polymerase III promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006383	transcription from RNA polymerase III promoter
GO:0010467	gene expression