InnateDB Protein
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IDBP-237142.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ZNF143
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Protein Name
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zinc finger protein 143
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Synonyms
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pHZ-1; SBF; STAF;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000379843
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InnateDB Gene
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IDBG-31360 (ZNF143)
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Protein Structure
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Function |
Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8. {ECO:0000269PubMed:17938208, ECO:0000269PubMed:9776743}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed in all tissues tested, with the strongest expression in ovary.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
5
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006359
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regulation of transcription from RNA polymerase III promoter
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0006383
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transcription from RNA polymerase III promoter
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GO:0010467
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gene expression
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Cellular Component |
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PDB ID |
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InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
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PFAM |
PF00096
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PRINTS |
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PIRSF |
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SMART |
SM00355
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TIGRFAMs |
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Modification |
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SwissProt |
P52747
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PhosphoSite |
PhosphoSite-P52747
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
7702
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UniGene |
Hs.707164
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RefSeq |
NP_001269586
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HUGO |
HGNC:12928
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OMIM |
603433
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CCDS |
CCDS60721
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HPRD |
04578
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IMGT |
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EMBL |
AC127030
AC132192
AF071771
AK291133
AK297214
AK313330
BC020219
U09850
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GenPept |
AAC50266
AAC96102
AAH20219
BAF83822
BAG59697
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