Version 5.4
| Homo sapiens Protein: CLEC12B | |||||
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| Summary | |||||
| InnateDB Protein | IDBP-237350.7 | ||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||
| Gene Symbol | CLEC12B | ||||
| Protein Name | C-type lectin domain family 12, member B | ||||
| Synonyms | |||||
| Species | Homo sapiens | ||||
| Ensembl Protein | ENSP00000379759 | ||||
| InnateDB Gene | IDBG-545208 (CLEC12B) | ||||
| Protein Structure |
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| UniProt Annotation | |||||
| Function | Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. {ECO:0000269PubMed:17562706}. | ||||
| Subcellular Localization | Cell membrane {ECO:0000269PubMed:17562706}; Single-pass type II membrane protein {ECO:0000269PubMed:17562706}. | ||||
| Disease Associations | |||||
| Tissue Specificity | Detected in colon, heart, kidney, liver, lung, mammary gland, ovary, spleen and testis. {ECO:0000269PubMed:17562706}. | ||||
| Comments | |||||
| Interactions | |||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||
| PDB ID | |||||
| InterPro |
IPR001304
C-type lectin IPR013600 Ly49-like N-terminal IPR016187 C-type lectin fold |
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| PFAM |
PF00059
PF08391 |
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| PRINTS | |||||
| PIRSF | |||||
| SMART |
SM00034
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| TIGRFAMs | |||||
| Post-translational Modifications | |||||
| Modification | |||||
| Cross-References | |||||
| SwissProt | Q2HXU8 | ||||
| PhosphoSite | PhosphoSite-Q2HXU8 | ||||
| TrEMBL | |||||
| UniProt Splice Variant | |||||
| Entrez Gene | 387837 | ||||
| UniGene | Hs.629334 | ||||
| RefSeq | NP_995324 | ||||
| HUGO | HGNC:31966 | ||||
| OMIM | |||||
| CCDS | CCDS8610 | ||||
| HPRD | 18266 | ||||
| IMGT | |||||
| EMBL | AK128243 AY358810 CH471094 DQ368812 | ||||
| GenPept | AAQ89170 ABC96323 BAC87350 EAW96136 | ||||