Version 5.4
Homo sapiens Protein: UBE2Q2
Summary
InnateDB Protein IDBP-23758.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE2Q2
Protein Name ubiquitin-conjugating enzyme E2Q family member 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000267938
InnateDB Gene IDBG-23756 (UBE2Q2)
Protein Structure
UniProt Annotation
Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. {ECO:0000269PubMed:20061386}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:16300736}.
Disease Associations
Tissue Specificity Detected in hypopharyngeal head and neck squamous cell carcinoma, in tumor masses and invasive epithelium. {ECO:0000269PubMed:16300736}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0070936 protein K48-linked ubiquitination
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000608 Ubiquitin-conjugating enzyme, E2
IPR006575 RWD domain
IPR016135 Ubiquitin-conjugating enzyme/RWD-like
PFAM PF00179
PF05773
PRINTS
PIRSF
SMART SM00591
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WVN8
PhosphoSite PhosphoSite-Q8WVN8
TrEMBL B4DFQ2
UniProt Splice Variant
Entrez Gene 92912
UniGene Hs.740413
RefSeq NP_775740
HUGO HGNC:19248
OMIM 612501
CCDS CCDS10286
HPRD 14294
IMGT
EMBL AC019294 AC027104 AK294199 AK296234 AL832429 BC006827 BC017708 BC034342
GenPept AAH06827 AAH17708 AAH34342 BAG57513 BAH12288 CAH10654

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca