InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KIAA0430

Summary

InnateDB Protein

IDBP-237644.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIAA0430

Protein Name

KIAA0430

Synonyms

LKAP; MARF1; PPP1R34;

Species

Homo sapiens

Ensembl Protein

ENSP00000379654

InnateDB Gene

IDBG-16071 (KIAA0430)

Protein Structure

UniProt Annotation

Function

Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity). {ECO:0000250}.

Subcellular Localization

Peroxisome {ECO:0000269PubMed:15932519}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003674	molecular_function
GO:0003676	nucleic acid binding
GO:0003723	RNA binding

Biological Process

GO:0006302	double-strand break repair
GO:0007143	female meiotic division
GO:0010468	regulation of gene expression
GO:0010923	negative regulation of phosphatase activity
GO:0048477	oogenesis