InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DYNC1LI1

Summary

InnateDB Protein

IDBP-23771.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DYNC1LI1

Protein Name

dynein, cytoplasmic 1, light intermediate chain 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000273130

InnateDB Gene

IDBG-23769 (DYNC1LI1)

Protein Structure

UniProt Annotation

Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress throuh the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. {ECO:0000269PubMed:19229290}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000269PubMed:19229290}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269PubMed:19229290}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	36 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006810	transport
GO:0007018	microtubule-based movement
GO:0007067	mitotic nuclear division
GO:0008152	metabolic process
GO:0016032	viral process
GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000922	spindle pole
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005868	cytoplasmic dynein complex
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0016020	membrane