InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PHLDA2

Summary

InnateDB Protein

IDBP-23776.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PHLDA2

Protein Name

pleckstrin homology-like domain, family A, member 2

Synonyms

BRW1C; BWR1C; HLDA2; IPL; TSSC3;

Species

Homo sapiens

Ensembl Protein

ENSP00000319231

InnateDB Gene

IDBG-23772 (PHLDA2)

Protein Structure

UniProt Annotation

Function

Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in placenta and adult prostate gland. In placenta, it is present in all cells of the villous cytotrophoblast. The protein is absent in cells from hydatidiform moles. Hydatidiform mole is a gestation characterized by abnormal development of both fetus and trophoblast. The majority of hydatidiform moles are associated with an excess of paternal to maternal genomes and are likely to result from the abnormal expression of imprinted genes (at protein level). Expressed at low levels in adult liver and lung, and fetal liver. Expressed in adult brain and neuroblastoma, medullablastoma and glioblastoma cell lines. {ECO:0000269PubMed:10594239, ECO:0000269PubMed:10749982, ECO:0000269PubMed:13129680, ECO:0000269PubMed:15457853, ECO:0000269PubMed:9328465}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0001890	placenta development
GO:0006915	apoptotic process
GO:0009887	organ morphogenesis
GO:0010468	regulation of gene expression
GO:0030334	regulation of cell migration
GO:0045995	regulation of embryonic development
GO:0070873	regulation of glycogen metabolic process