Version 5.4
Homo sapiens Protein: MRGPRX3
Summary
InnateDB Protein IDBP-237855.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRGPRX3
Protein Name MAS-related GPR, member X3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000379571
InnateDB Gene IDBG-34549 (MRGPRX3)
Protein Structure
UniProt Annotation
Function Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons. {ECO:0000269PubMed:11850634}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96LB0
PhosphoSite PhosphoSite-
TrEMBL E9PPY5
UniProt Splice Variant
Entrez Gene 117195
UniGene Hs.380177
RefSeq NP_473372
HUGO HGNC:17980
OMIM 607229
CCDS CCDS7830
HPRD 06248
IMGT
EMBL AC090099 AF474987 AF474988 AY042215 BC067292 CH471064 EU432126
GenPept AAH67292 AAK91806 AAL86878 AAL86879 ABY87925 EAW68417

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca