Version 5.4
Homo sapiens Protein: STAP1
Summary
InnateDB Protein IDBP-237957.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STAP1
Protein Name signal transducing adaptor family member 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000379527
InnateDB Gene IDBG-21034 (STAP1)
Protein Structure
UniProt Annotation
Function In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC. {ECO:0000269PubMed:10518561}.
Subcellular Localization Nucleus {ECO:0000269PubMed:17936702}. Cytoplasm {ECO:0000269PubMed:17936702}. Mitochondrion {ECO:0000269PubMed:17936702}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006886 intracellular protein transport
GO:0007165 signal transduction
GO:0061025 membrane fusion
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR000980 SH2 domain
IPR001849 Pleckstrin homology domain
PFAM PF00017
PF14633
PF00169
PRINTS PR00401
PIRSF
SMART SM00252
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9ULZ2
PhosphoSite PhosphoSite-Q9ULZ2
TrEMBL A0A024RD91
UniProt Splice Variant
Entrez Gene 26228
UniGene Hs.435579
RefSeq XP_005265732
HUGO HGNC:24133
OMIM 604298
CCDS CCDS3515
HPRD 16053
IMGT
EMBL AB023483 AK313676 BC014958 CH471057
GenPept AAH14958 BAA85311 BAG36427 EAX05547 EAX05548

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca