Version 5.4
Homo sapiens Protein: CCK
Summary
InnateDB Protein IDBP-238072.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCK
Protein Name cholecystokinin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000379472
InnateDB Gene IDBG-27657 (CCK)
Protein Structure
UniProt Annotation
Function This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0005184 neuropeptide hormone activity
GO:0005515 protein binding
Biological Process
GO:0001662 behavioral fear response
GO:0001764 neuron migration
GO:0001836 release of cytochrome c from mitochondria
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 signal transduction
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007409 axonogenesis
GO:0008284 positive regulation of cell proliferation
GO:0032099 negative regulation of appetite
GO:0032461 positive regulation of protein oligomerization
GO:0042755 eating behavior
GO:0043065 positive regulation of apoptotic process
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051901 positive regulation of mitochondrial depolarization
GO:0051930 regulation of sensory perception of pain
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0030424 axon
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0043194 axon initial segment
GO:0043195 terminal bouton
GO:0043203 axon hillock
GO:0043204 perikaryon
Protein Structure and Domains
PDB ID
InterPro IPR001651 Gastrin/cholecystokinin peptide hormone
PFAM PF00918
PRINTS
PIRSF
SMART SM00029
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P06307
PhosphoSite PhosphoSite-P06307
TrEMBL Q6FG82
UniProt Splice Variant
Entrez Gene 885
UniGene Hs.458426
RefSeq NP_000720
HUGO HGNC:1569
OMIM 118440
CCDS CCDS2696
HPRD 00321
IMGT
EMBL AK289716 AY514491 BC008283 BC093055 BC111026 BT006991 CH471055 CR542226 L00354
GenPept AAA53094 AAH08283 AAH93055 AAI11027 AAP35637 AAR89908 BAF82405 CAG47022 EAW64644 EAW64645

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca