Version 5.4
Homo sapiens Protein: GREB1
Summary
InnateDB Protein IDBP-238128.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GREB1
Protein Name growth regulation by estrogen in breast cancer 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000379429
InnateDB Gene IDBG-29963 (GREB1)
Protein Structure
UniProt Annotation
Function May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.
Subcellular Localization Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in proliferating prostatic tissue and prostate cancer. {ECO:0000269PubMed:16496412}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q4ZG55
PhosphoSite PhosphoSite-Q4ZG55
TrEMBL
UniProt Splice Variant
Entrez Gene 9687
UniGene Hs.611740
RefSeq XP_005246254
HUGO HGNC:24885
OMIM 611736
CCDS
HPRD 13611
IMGT
EMBL AB011147 AC011994 AC110754 AF245388 AF245389 AF245390 BC054502 CH471053
GenPept AAG39036 AAG39037 AAG39038 AAH54502 AAX88907 BAA25501 EAX00927 EAX00928

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca