InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UMOD

Summary

InnateDB Protein

IDBP-238134.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UMOD

Protein Name

uromodulin

Synonyms

ADMCKD2; FJHN; HNFJ; HNFJ1; MCKD2; THGP; THP;

Species

Homo sapiens

Ensembl Protein

ENSP00000379438

InnateDB Gene

IDBG-18285 (UMOD)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019864	IgG binding

Biological Process

GO:0006968	cellular defense response
GO:0007157	heterophilic cell-cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007588	excretion
GO:0008285	negative regulation of cell proliferation
GO:0010033	response to organic substance
GO:0048878	chemical homeostasis
GO:0072218	metanephric ascending thin limb development
GO:0072221	metanephric distal convoluted tubule development
GO:0072233	metanephric thick ascending limb development
GO:1990266	neutrophil migration
GO:2000021	regulation of ion homeostasis

Cellular Component

GO:0000922	spindle pole
GO:0005615	extracellular space
GO:0005794	Golgi apparatus
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0019898	extrinsic component of membrane
GO:0031225	anchored component of membrane
GO:0031410	cytoplasmic vesicle
GO:0045121	membrane raft
GO:0045177	apical part of cell
GO:0060170	ciliary membrane
GO:0070062	extracellular vesicular exosome
GO:0072372	primary cilium

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001507 Zona pellucida domain
IPR001881 EGF-like calcium-binding domain
IPR009030 Insulin-like growth factor binding protein, N-terminal

PFAM

PF00008
PF00100
PF07645

PRINTS

PR00023

PIRSF

SMART

SM00181
SM00241
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt