InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADAMTS6

Summary

InnateDB Protein

IDBP-23825.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAMTS6

Protein Name

ADAM metallopeptidase with thrombospondin type 1 motif, 6

Synonyms

ADAM-TS 6; ADAM-TS6; ADAMTS-6;

Species

Homo sapiens

Ensembl Protein

ENSP00000370443

InnateDB Gene

IDBG-23823 (ADAMTS6)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at low levels in placenta and barely detectable in a number of other tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508

proteolysis

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000884 Thrombospondin, type 1 repeat
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR002870 Peptidase M12B, propeptide
IPR010294 ADAM-TS Spacer 1
IPR010909 PLAC
IPR013273 Peptidase M12B, ADAM-TS

PFAM

PF00090
PF01421
PF01562
PF05986
PF08686

PRINTS

PR01857

PIRSF

SMART

SM00209

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt