InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNASE6

Summary

InnateDB Protein

IDBP-2383.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNASE6

Protein Name

ribonuclease, RNase A family, k6

Synonyms

RAD1; RNasek6; RNS6;

Species

Homo sapiens

Ensembl Protein

ENSP00000302046

InnateDB Gene

IDBG-2381 (RNASE6)

Protein Structure

UniProt Annotation

Function

May have a role in host defense.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Strong expression in lung, followed by heart, placenta, kidney, pancreas, liver, brain and skeletal muscle. Also expressed in monocytes and neutrophils.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004540	ribonuclease activity
GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters

Biological Process

GO:0006401	RNA catabolic process
GO:0006952	defense response
GO:0090501	RNA phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic

Cellular Component

GO:0005576	extracellular region
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001427 Pancreatic ribonuclease
IPR023412 Ribonuclease A-domain

PFAM

PF00074

PRINTS

PR00794

PIRSF

SMART

SM00092

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AK313580 BC020848 CH471078 CR456965 HG328838 U64998

GenPept

AAC51848 AAH20848 BAG36350 CAG33246 CDG31914 EAW66440 EAW66441 EAW66442

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca