InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MOB1A

Summary

InnateDB Protein

IDBP-238320.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MOB1A

Protein Name

MOB kinase activator 1A

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000379364

InnateDB Gene

IDBG-56966 (MOB1A)

Protein Structure

UniProt Annotation

Function

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. {ECO:0000269PubMed:15197186, ECO:0000269PubMed:18362890, ECO:0000269PubMed:19739119}.

Subcellular Localization

Disease Associations

Tissue Specificity

Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver. {ECO:0000269PubMed:19739119}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.